Treatment and outcome of undifferentiated carcinoma of the nasopharynx in childhood: A 13‐year experience
Identifieur interne : 001693 ( Main/Exploration ); précédent : 001692; suivant : 001694Treatment and outcome of undifferentiated carcinoma of the nasopharynx in childhood: A 13‐year experience
Auteurs : Charles A. Lobo-Sanahuja [Costa Rica] ; Ivette Garcia [Costa Rica] ; Alfonso Carranza [Costa Rica] ; Alvaro Camacho [Costa Rica]Source :
- Medical and Pediatric Oncology [ 0098-1532 ] ; 1986.
English descriptors
Abstract
Between 1970 and 1983, 22 pediatric patients diagnosed as having undifferentiated nasopharyngeal carcinoma (UNC) were treated at the National Children's Hospital of Costa Rica; primary tumor with local extension (T3‐T4) was present in 45% of the patients, and metastasis of the cervical nodes (N1‐N3) in 82%. Patients were divided into groups A and B according to the type of treatment received. A description of both groups is as follows. Ten patients were treated with 5,000 to 6,000 rads tumor dose to the primary and a 5,125‐rad dose was administered to the lower neck between 1970 and 1977 (group A). Six patients received postradiation therapy with cyclophosphamide and vincristine and two patients also received 5‐fluorouracil. The outcome in group A was as follows: four (40%) failed to respond, six (60%) achieved full remission initially with two subsequent relapses, and the remaining four are still alive and free of relapse after 90 to 160 months (average 130) (two were treated with Co60 alone and two with chemotherapy. Twelve patients were treated with chemotherapy pre‐ and postradiation with CPM and adriamycin for a total of 12 months (group B) between 1978 and 1984. All (100%) achieved complete initial remission; two patients relapsed and died. Ten patients have remained in relapse‐free survival for 18–67 months (median 32). Though this is not a controlled study, our experience indicates that pre‐ and postradiation chemotherapy is effective in prolonging the disease‐free survival in UNC and may allow a decrease of the radiation tumor dose.
Url:
DOI: 10.1002/mpo.2950140103
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000571
- to stream Istex, to step Curation: 000273
- to stream Istex, to step Checkpoint: 000E65
- to stream Main, to step Merge: 001753
- to stream Main, to step Curation: 001693
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment and outcome of undifferentiated carcinoma of the nasopharynx in childhood: A 13‐year experience</title><author><name sortKey="Lobo Anahuja, Charles A" sort="Lobo Anahuja, Charles A" uniqKey="Lobo Anahuja C" first="Charles A." last="Lobo-Sanahuja">Charles A. Lobo-Sanahuja</name></author><author><name sortKey="Garcia, Ivette" sort="Garcia, Ivette" uniqKey="Garcia I" first="Ivette" last="Garcia">Ivette Garcia</name></author><author><name sortKey="Carranza, Alfonso" sort="Carranza, Alfonso" uniqKey="Carranza A" first="Alfonso" last="Carranza">Alfonso Carranza</name></author><author><name sortKey="Camacho, Alvaro" sort="Camacho, Alvaro" uniqKey="Camacho A" first="Alvaro" last="Camacho">Alvaro Camacho</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:57BD30A951CC8FE73A26BC49CC2A270FF9187581</idno><date when="1986" year="1986">1986</date><idno type="doi">10.1002/mpo.2950140103</idno><idno type="url">https://api.istex.fr/document/57BD30A951CC8FE73A26BC49CC2A270FF9187581/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000571</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000571</idno><idno type="wicri:Area/Istex/Curation">000273</idno><idno type="wicri:Area/Istex/Checkpoint">000E65</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000E65</idno><idno type="wicri:doubleKey">0098-1532:1986:Lobo Anahuja C:treatment:and:outcome</idno><idno type="wicri:Area/Main/Merge">001753</idno><idno type="wicri:Area/Main/Curation">001693</idno><idno type="wicri:Area/Main/Exploration">001693</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Treatment and outcome of undifferentiated carcinoma of the nasopharynx in childhood: A 13‐year experience</title><author><name sortKey="Lobo Anahuja, Charles A" sort="Lobo Anahuja, Charles A" uniqKey="Lobo Anahuja C" first="Charles A." last="Lobo-Sanahuja">Charles A. Lobo-Sanahuja</name><affiliation wicri:level="1"><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Divisions of Pediatric Oncology, Hospital Nacional de Niños, San José</wicri:regionArea><wicri:noRegion>San José</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Ivette" sort="Garcia, Ivette" uniqKey="Garcia I" first="Ivette" last="Garcia">Ivette Garcia</name><affiliation wicri:level="1"><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Divisions of Pediatric Oncology, Hospital Nacional de Niños, San José</wicri:regionArea><wicri:noRegion>San José</wicri:noRegion></affiliation></author><author><name sortKey="Carranza, Alfonso" sort="Carranza, Alfonso" uniqKey="Carranza A" first="Alfonso" last="Carranza">Alfonso Carranza</name><affiliation wicri:level="1"><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Divisions of Pathology, Hospital Nacional de Niños, San José</wicri:regionArea><wicri:noRegion>San José</wicri:noRegion></affiliation></author><author><name sortKey="Camacho, Alvaro" sort="Camacho, Alvaro" uniqKey="Camacho A" first="Alvaro" last="Camacho">Alvaro Camacho</name><affiliation wicri:level="1"><country xml:lang="fr">Costa Rica</country><wicri:regionArea>Department of Radiology, Hospital San Juan de Dios, San José</wicri:regionArea><wicri:noRegion>San José</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical and Pediatric Oncology</title><title level="j" type="abbrev">Med. Pediatr. Oncol.</title><idno type="ISSN">0098-1532</idno><idno type="eISSN">1096-911X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1986">1986</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="6">6</biblScope><biblScope unit="page" to="11">11</biblScope></imprint><idno type="ISSN">0098-1532</idno></series><idno type="istex">57BD30A951CC8FE73A26BC49CC2A270FF9187581</idno><idno type="DOI">10.1002/mpo.2950140103</idno><idno type="ArticleID">MPO2950140103</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0098-1532</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>chemotherapy</term><term>childhood cancer</term><term>nasopharyngeal carcinoma</term><term>radiotherapy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Between 1970 and 1983, 22 pediatric patients diagnosed as having undifferentiated nasopharyngeal carcinoma (UNC) were treated at the National Children's Hospital of Costa Rica; primary tumor with local extension (T3‐T4) was present in 45% of the patients, and metastasis of the cervical nodes (N1‐N3) in 82%. Patients were divided into groups A and B according to the type of treatment received. A description of both groups is as follows. Ten patients were treated with 5,000 to 6,000 rads tumor dose to the primary and a 5,125‐rad dose was administered to the lower neck between 1970 and 1977 (group A). Six patients received postradiation therapy with cyclophosphamide and vincristine and two patients also received 5‐fluorouracil. The outcome in group A was as follows: four (40%) failed to respond, six (60%) achieved full remission initially with two subsequent relapses, and the remaining four are still alive and free of relapse after 90 to 160 months (average 130) (two were treated with Co60 alone and two with chemotherapy. Twelve patients were treated with chemotherapy pre‐ and postradiation with CPM and adriamycin for a total of 12 months (group B) between 1978 and 1984. All (100%) achieved complete initial remission; two patients relapsed and died. Ten patients have remained in relapse‐free survival for 18–67 months (median 32). Though this is not a controlled study, our experience indicates that pre‐ and postradiation chemotherapy is effective in prolonging the disease‐free survival in UNC and may allow a decrease of the radiation tumor dose.</div></front></TEI><affiliations><list><country><li>Costa Rica</li></country></list><tree><country name="Costa Rica"><noRegion><name sortKey="Lobo Anahuja, Charles A" sort="Lobo Anahuja, Charles A" uniqKey="Lobo Anahuja C" first="Charles A." last="Lobo-Sanahuja">Charles A. Lobo-Sanahuja</name></noRegion><name sortKey="Camacho, Alvaro" sort="Camacho, Alvaro" uniqKey="Camacho A" first="Alvaro" last="Camacho">Alvaro Camacho</name><name sortKey="Carranza, Alfonso" sort="Carranza, Alfonso" uniqKey="Carranza A" first="Alfonso" last="Carranza">Alfonso Carranza</name><name sortKey="Garcia, Ivette" sort="Garcia, Ivette" uniqKey="Garcia I" first="Ivette" last="Garcia">Ivette Garcia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001693 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001693 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= CobaltMaghrebV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:57BD30A951CC8FE73A26BC49CC2A270FF9187581
|texte= Treatment and outcome of undifferentiated carcinoma of the nasopharynx in childhood: A 13‐year experience
}}
| This area was generated with Dilib version V0.6.32. |  |